Clindoxyl Gel (Clindamycin/Benzoyl Peroxide)

Description

Clindoxyl Gel is a topical medicine that is commonly prescribed to treat acne. It contains two active ingredients: clindamycin which is an antibiotic, as well as benzoyl Peroxide an antimicrobial agent that has Keratolytic properties. Here’s a complete description of Clindoxyl Gel:

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Active Ingredients

1. Clindamycin:
   • Type Antibiotic (Lincosamide class).
   • Mechanism Inhibits the synthesis of bacterial proteins through binding to ribosomal subunit 50S and thereby preventing the growth of bacteria and reducing inflammation that is associated with acne.
2. Benzoyl Peroxide:
   • Type Antimicrobial and Keratolytic agent.
   • Mechanism kills bacteria (specifically Propionibacterium acnes which is a major factor in acne) and assists in peeling off the skin’s outer layer which reduces the formation of comedones and pimples.

Indications

Clindoxyl Gel is used primarily for treating moderate or severe acne vulgaris primarily pustules and papules.

How to Use Clindoxyl Gel?

• Application Apply a thin coating Clindoxyl Gel on the areas affected by the sun every day, preferably at night or as directed by your healthcare physician.
• Preparation Cleanse the skin gently prior to application and make sure it’s dry. Avoid applying the cream to broken skin or mucous membranes (e.g. inside the mouth or nose).
• Duration The duration of treatment is variable but the most noticeable improvement occurs within 4 to 6 weeks. The continuous use of the treatment as prescribed is necessary for the optimal results.

What is a Clindoxyl Gel Side Effects?

Common side effects could include:

• Skin peeling or dryness.
• The application site may be irritated or red. application site.
• A burning or itching sensation.

Rare, but serious adverse effects can include:

• Extreme allergic reactions (rash swelling, itching extreme dizziness, difficulty breathing).
• Persistent diarrhea or colitis due to clindamycin’s potential to cause antibiotic-associated colitis.

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Precautions

• Allergies Inform your physician of any allergy to clindamycin benzoyl peroxide, or other medication.
• Medical Conditions Discuss any pre-existing illnesses, particularly gastrointestinal disorders (e.g. colitis, e.g.).
• Other Medicines Inform your doctor about any other topical medications or acne treatments that you are using to prevent potential interactions.

Storage

• Keep the Clindoxyl Gel at room temperature Keep away from light and moisture.
• Keep the container tightly shut whenever not in use.
• Don’t freeze.

Special Considerations

• Pregnancy and breastfeeding Consult a medical professional prior to using. While topical clindamycin has a low absorption into the system but caution is still recommended.
• Sun Exposition: Benzoyl peroxide may increase the sensitivity of skin to sunlight. Wear sunscreen and protective clothing when you are outdoors.

Effectiveness

Clindoxyl Gel is considered effective because of its dual-action approach that targets bacteria, and helps reduce inflammation while benzoyl Peroxide reduces the amount of bacteria and assists to exfoliate the skin. Studies have proven that the combination of both ingredients can reduce the severity and frequency of acne lesions when compared to using each component on its own.

Mechanism of Action

• Antimicrobial Effect The Benzoyl peroxide molecule creates free radicals that destroy bacterial proteins and cause the death of bacteria’s cells.
• Anti-inflammatory action: Clindamycin reduces inflammation by reducing the production of inflammation-related cells.