Co-Trimoxazole 960 mg (Sulfamethoxazole/Trimethoprim)

Description

Co-Trimoxazole 960 mg (Sulfamethoxazole/Trimethoprim) is an antibiotic medication that is typically administered orally in tablets. It contains two active components: sulfamethoxazole as well as trimetho which help to block the growth of bacteria by interfering the production of folic acids in bacteria. Here’s a comprehensive overview:

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Composition

• Sulfamethoxazole: 800 mg
• Trimethoprim: 160 mg
• Total: 996 mg

Mechanism of Action

Co-Trimoxazole 960 mg is a combination of the benefits of sulfamethoxazole with trimethoprim.

• Sulfamethoxazole inhibits the synthesis of dihydropteroate an folic acid precursor in bacteria.
• Trimethoprim Inhibits dihydrofolate reducetase another enzyme that is involved in the folic acid pathway.

Indications

Co-Trimoxazole is a treatment for various infections caused by bacteria, including:

• Urinary tract infections (UTIs)
• Respiratory illnesses (such as pneumonia and bronchitis)
• Gastrointestinal diseases (such as traveler’s diarrhoea and the shigellosis)
• Certain kinds of meningitis
• Pneumocystis Jiroveci pneumonia (especially in immunocompromised patients like those with HIV/AIDS)

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Co-Trimoxazole 960 mg Dosage and Administration

The standard adult dosage is tablet of 960 mg each 12 hours. However, dosages can vary depending on the condition being treated and the specific patient factors.

Contraindications

• There is a history of hypersensitivity to sulfamethoxazole trimethoprim, or other Sulfonamides.
• Kidney or liver impairments that are severe.
• Blood dyscrasias (blood disorders).
• Pregnancy, especially in the first trimester as well as breastfeeding.

What is a Co-Trimoxazole 960 mg Side Effects?

Common side effects can include:

• Nausea and vomiting
• Diarrhea
• Rash
• Appetite loss
• Allergic reactions, which may be extremely severe (e.g. Stevens-Johnson syndrome epidermal necrolysis toxic to the skin)

The less common, but potentially serious side effects are:

• Disorders of the blood (e.g. the thrombocytopenia leukopenia, etc.)
• Kidney or liver issues
• Hyperkalemia (high levels of potassium)
• Very severe allergic reactions

Interactions

Co-Trimoxazole 960 mg may be a drug that interacts with other medicines, including:

• Blood thinners (e.g. warfarin, for instance)
• Certain diuretics
• Potassium-suppressing medications
• Methotrexate
• Phenytoin

Monitoring

Patients taking Co-Trimoxazole 960 mg must be screened for:

• The signs of an allergic reaction
• Blood counts, particularly when used for a long time
• Renal function
• Potassium levels are high, particularly in patients who are at risk of hyperkalemia

Precautions

• Patients must drink plenty of water to avoid crystalluria and kidney stones.
• Be aware of patients who are elderly or have an existing renal or hepatic condition.
• Regular blood tests are required for patients who are on long-term treatment.

Storage

Keep Co-Trimoxazole 960 mg in a cool, dry place far from direct light and moisture.