Imutrex 7.5 mg (Methotrexate)

Description

Imutrex 7.5 mg Generic Name:

• Methotrexate

Brand Name:

• Imutrex

Dosage Form:

• Tablet

Strength:

• 7.5 mg

Mechanism of Action:

• Methotrexate is an antimetabolite and antifolate drug. It works by inhibiting the enzyme dihydrofolate reductase, which is crucial for DNA synthesis and cell reproduction. This inhibition affects rapidly dividing cells, such as cancer cells, immune cells, and the cells involved in inflammatory processes.

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Imutrex 7.5 mg Uses/Indications:

• Rheumatoid Arthritis: Reduces inflammation and slows disease progression.
• Psoriasis: Controls severe psoriasis by slowing down the growth of skin cells.
• Cancer: Used Imutrex 7.5 mg in various types of cancer like leukemia, breast cancer, lung cancer, and lymphoma.
• Ectopic Pregnancy: Sometimes used in the medical management of ectopic pregnancy.

Imutrex 7.5 mg Dosage and Administration:

• Rheumatoid Arthritis and Psoriasis: Typically started at a low dose, often 7.5 mg once weekly, which can be adjusted based on the patient’s response and tolerability.
• Cancer: Dosage varies widely depending on the type of cancer, treatment regimen, and patient factors. It can be given orally, intramuscularly, intravenously, or intrathecally (directly into the cerebrospinal fluid).

Contraindications:

• Hypersensitivity to methotrexate.
• Severe liver or kidney disease.
• Blood disorders (e.g., leukopenia, thrombocytopenia).
• Pregnancy and breastfeeding.
• Alcoholism.

What is a Imutrex 7.5 mg Side Effects?

• Common:
  • Nausea, vomiting.
  • Mouth sores.
  • Fatigue.
  • Dizziness.
  • Abdominal pain.
• Serious:
  • Liver toxicity (hepatitis, fibrosis, cirrhosis).
  • Bone marrow suppression (anemia, leukopenia, thrombocytopenia).
  • Lung toxicity (interstitial pneumonitis).
  • Kidney damage.
  • Severe skin reactions.
  • Increased risk of infections.
  • Gastrointestinal perforation.

Monitoring:

• Regular blood tests to monitor liver function, kidney function, and blood cell counts.
• Chest X-rays and pulmonary function tests for lung toxicity.
• Regular follow-ups with the healthcare provider to assess the effectiveness and side effects.

Drug Interactions:

• NSAIDs: Can increase methotrexate levels, leading to toxicity.
• Antibiotics (e.g., penicillins, sulfonamides): Can interfere with methotrexate elimination.
• Probenecid: Increases methotrexate levels.
• Folic Acid: Reduces the efficacy of methotrexate.
• Alcohol: Increases the risk of liver toxicity.

Related Pills: Imutrex 2.5 mg (Methotrexate) | Lefumide 20 mg (Leflunomide) | Lefumide 10 mg (Leflunomide)

Precautions:

• Pregnancy: Methotrexate is teratogenic and contraindicated during pregnancy.
• Breastfeeding: Methotrexate can pass into breast milk and is contraindicated.
• Alcohol Consumption: Should be avoided due to increased risk of liver damage.
• Infection Risk: Patients should avoid exposure to infections due to immunosuppression.

Special Populations:

• Elderly: May be more susceptible to side effects, especially liver and kidney toxicity.
• Children: Imutrex 7.5 mg Dosage adjustments are necessary; monitoring is critical.
• Patients with Renal Impairment: Dosage adjustment required; increased monitoring for toxicity.

Overdose Management:

• Symptoms: Severe bone marrow suppression, mucositis, liver damage, and renal failure.
• Treatment: Immediate medical attention, folinic acid (leucovorin) rescue, supportive care, and possibly hemodialysis for drug removal.

Patient Education:

• Adherence: Importance of taking the medication exactly as prescribed.
• Signs of Side Effects: Educating about symptoms like unusual bleeding, bruising, persistent cough, and shortness of breath.
• Avoiding Infections: Hand hygiene, avoiding close contact with sick individuals.
• Contraception: Effective birth control methods should be used during treatment and for a period after stopping methotrexate (usually six months for women and three months for men).

Storage:

• Store Imutrex 7.5 mg at room temperature away from light and moisture.
• Keep out of reach of children.

Generic Availability:

• Yes, methotrexate is available in generic form, which might be more affordable.