Molnupiravir 200 mg (Cipmolnu)

Description

Molnupiravir 200 mg, marketed under the brand name Cipmolnu by Cipla, is an antiviral medication used to treat COVID-19. It was originally developed for the treatment of influenza, but its efficacy against SARS-CoV-2, the virus responsible for COVID-19, led to its emergency use authorization and approval in several countries.

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Mechanism of Action

Molnupiravir 200 mg is a prodrug that, once ingested, is metabolized into its active form, N-hydroxycytidine. This compound mimics the natural nucleosides used by the SARS-CoV-2 virus to replicate its RNA. When incorporated into the viral RNA during replication, it causes an increased frequency of mutations (known as “error catastrophe”), ultimately inhibiting the replication of the virus.

Indications

Molnupiravir tablets is indicated for the treatment of mild to moderate COVID-19 in adults who are at risk of progressing to severe disease, including hospitalization or death. It is especially used in patients for whom alternative COVID-19 treatment options authorized by the health authorities are not accessible or appropriate.

Molnupiravir 200 mg Dosage and Administration

• Strength: 200 mg per capsule
• Dosage: The recommended dosage is 800 mg (four 200 mg capsules) taken orally every 12 hours for 5 days.
• Administration: Molnupiravir should be taken with or without food, but it’s important to complete the full 5-day course even if symptoms improve early.

Contraindications

• Hypersensitivity to molnupiravir or any of its components.

Precautions and Warnings

• Pregnancy and Lactation: Molnupiravir 200 mg is not recommended for use during pregnancy. Women of childbearing potential should use effective contraception during treatment and for a specified period after the last dose. Lactating women should not breastfeed during treatment and for a specified period after the final dose.
• Renal and Hepatic Impairment: There is limited data on the use of molnupiravir in patients with severe renal or hepatic impairment.
• Drug Interactions: There are no significant drug-drug interactions known with molnupiravir.

What is a Molnupiravir 200 mg Side Effects?

Common side effects of molnupiravir include:

• Diarrhea
• Nausea
• Dizziness
• Headache

Most side effects are mild to moderate and usually resolve without the need for discontinuation of the drug.

Related Pills:  Antiflu 75 mg (Oseltamivir) | Acivir Eye Ointment (Acyclovir) | Acivir DT 800 mg (Acyclovir)

Clinical Trials and Efficacy

Molnupiravir has been evaluated in several clinical trials, including the MOVe-OUT study, which demonstrated a reduction in the risk of hospitalization or death in non-hospitalized adults with COVID-19 who were at high risk for severe illness. The trials indicated that early treatment with molnupiravir can lead to a significant reduction in viral load.

Storage

Store Molnupiravir 200 mg capsules at room temperature, away from light and moisture. Keep out of reach of children.