Votrient 400 mg (Pazopanib)

Description

Votrient 400 mg (Pazopanib) is an oral medication used primarily for the treatment of certain types of cancer. Below is comprehensive information about Votrient 400 mg:

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What is Votrient 400 mg?

Votrient 400 mg, with the active ingredient pazopanib, is a tyrosine kinase inhibitor. It works by blocking the growth of cancer cells and slowing their spread in the body.

Votrient 400 mg Uses

Votrient 400 mg is primarily used for:

1. Advanced Renal Cell Carcinoma (RCC): A type of kidney cancer.
2. Advanced Soft Tissue Sarcoma (STS): A group of cancers that begin in the tissues that connect, support, or surround other structures and organs of the body.

How It Works

Pazopanib inhibits several tyrosine kinases, which are enzymes responsible for the activation of various proteins by signal transduction cascades. By blocking these enzymes, Votrient 400 mg interferes with the growth and proliferation of cancer cells.

Votrient 400 mg Dosage and Administration

• Standard Dose: The usual dose is 800 mg once daily, but it can vary based on individual patient needs and response to the medication.
• How to Take: It should be taken on an empty stomach, at least one hour before or two hours after a meal. Swallow the tablet whole with water; do not crush or chew the tablets.
• Missed Dose: If you miss a dose and it’s less than 12 hours until your next dose, skip the missed dose. Do not take extra medicine to make up the missed dose.

Related Pills:  Votrient 200 mg (Pazopanib) | Viraday 300 mg/200 mg/600 mg | Velpanat 400mg/100mg (Sofosbuvir/Velpatasvir)

Votrient 400 mg Side Effects

Common side effects include:

• Diarrhea
• Hypertension (high blood pressure)
• Changes in hair color
• Nausea and vomiting
• Fatigue
• Loss of appetite
• Abdominal pain

Serious side effects may include:

• Liver toxicity
• Cardiac dysfunction, such as heart attack or heart failure
• Thrombotic events (blood clots)
• Severe bleeding
• Gastrointestinal perforation (tear in the stomach or intestines)
• Reversible posterior leukoencephalopathy syndrome (a rare condition affecting the brain)

Precautions

• Liver Function: Regular liver function tests are necessary as Votrient can cause liver damage.
• Heart Health: Regular monitoring of blood pressure and heart function is essential.
• Pregnancy and Breastfeeding: Votrient can harm an unborn baby, so it is not recommended during pregnancy. Breastfeeding is also not recommended during treatment.
• Drug Interactions: Inform your healthcare provider about all medications you are taking, as Votrient can interact with several drugs, including blood thinners and certain antibiotics.

Contraindications

• Known hypersensitivity to pazopanib or any component of the formulation.
• Severe hepatic impairment.

Storage

Store Votrient at room temperature, away from moisture and heat. Keep it out of reach of children.

Monitoring and Follow-up

Patients on Votrient 400 mg should have regular follow-ups with their healthcare provider to monitor:

• Blood pressure
• Liver function tests
• Electrocardiograms (ECGs) for heart rhythm
• Complete blood counts