Description
Zelgor 250 mg is a medication that contains abiraterone acetate, a drug used primarily in the treatment of prostate cancer. Here is a comprehensive overview of Zelgor 250 mg:
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Composition and Form
- Active Ingredient: Abiraterone acetate
- Dosage Form: Oral tablets
- Strength: 250 mg per tablet
Indications
- Prostate Cancer: Zelgor 250 mg is indicated for the treatment of metastatic castration-resistant prostate cancer (mCRPC) in men.
Mechanism of Action
Zelgor 250 mg (Abiraterone) acetate works by inhibiting the enzyme CYP17A1, which is involved in the production of androgens (male hormones). Since prostate cancer growth is often driven by androgens, reducing their levels helps in slowing the progression of the disease.
Zelgor 250 mg Dosage and Administration
- Standard Dosage: The typical dose is 1,000 mg (four 250 mg tablets) taken once daily.
- Administration: Should be taken on an empty stomach. No food should be eaten for at least two hours before the dose and for at least one hour after the dose. Swallow tablets whole with water.
- Combination with Prednisone: Abiraterone is often prescribed in combination with prednisone to help manage side effects and enhance efficacy.
Related Pills: Zecyte 500 mg (Abiraterone) | Zecyte 250 mg (Abiraterone) | Xpreza 100 mg (Azacitidine)
Zelgor 250 mg Side Effects
Common side effects include:
- Fatigue
- Joint swelling or pain
- Edema (swelling)
- Hot flashes
- Diarrhea
- Hypertension (high blood pressure)
- Hypokalemia (low potassium levels)
Less common but more serious side effects include:
- Liver toxicity
- Adrenal insufficiency
- Cardiac disorders (such as heart failure or arrhythmias)
Monitoring
Patients on Zelgor should have regular monitoring of liver function, blood pressure, and electrolyte levels, particularly potassium. Regular follow-up with healthcare providers is essential to manage any side effects and to adjust the dose if necessary.
Contraindications and Precautions
- Contraindications: Hypersensitivity to abiraterone acetate or any other component of the product.
- Precautions:
- Use with caution in patients with liver impairment.
- It is not recommended for use in women, especially those who are pregnant or may become pregnant, due to potential harm to the fetus.
- Patients with cardiovascular disease should be monitored closely.
Drug Interactions
Abiraterone can interact with several other medications, including:
- CYP3A4 substrates (e.g., statins, antifungal medications)
- Drugs that affect the QT interval
- Medications that influence potassium levels
Storage
- Temperature: Store at room temperature (15-30°C or 59-86°F).
- Protection: Keep in a dry place, away from moisture and direct sunlight. Keep out of reach of children.
Additional information
Tablet/s | 120 Tablet/s, 180 Tablet/s, 240 Tablet/s |
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